Cotinine is a significant metabolite of nicotine. In addition, the highest vs lowest tertile of serum cotinine degree was considerably associated with 30% elevated odds of kidney stones. Analyses of information from 19,405 contributors within the 2011-2018 National Health and Nutrition Examination Survey (NHANES) showed that energetic cigarette smoking is considerably associated with 30% increased odds of kidney stones in contrast with never smoking after adjustment for a number of variables, Jie Tang, MD, of Brown University in Providence, Rhode Island, and colleagues reported in a poster presentation.

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Tang J, Choncol M, Raker CA, Sammartino C. Cigarette smoking and prevalent kidney stone: The Nationwide Health and Nutrition Examination Survey 2011-2018. Introduced at: Clearance E-Liquids Kidney Week 2023; November 2-5, Philadelphia, Pennsylvania.